One of the the most basic principals of interior design is that every room needs a focal point, or a single design element that will instantly draw the eye into the space and give the viewer a sense of what to expect. It goes without saying that a great piece of wall art could easily fulfill this position.
While some pieces may be two-dimensional paintings or something similar, you should try to find art in a variety of different mediums to help bring a varying sense of texture into the space.